PDRN: The Unique Ingredient Behind Korean Cosmetics
- 동훈 Jason 임
- May 14
- 3 min read
Updated: May 22
PDRN is The New Skincare Ingredient Taking Over Korean Cosmetics

Did you know that even skincare ingredients follow trends? Just like hyaluronic acid and peptides once dominated the beauty scene, PDRN is now making waves as the next big thing in korean cosmetics.
Never heard of PDRN before? No worries — at Nextpangaea, we’re here to break it down. From what PDRN actually is to how it works, plus its pros and cons, we’ve got you covered.
Whether you’re a skincare enthusiast or simply intrigued by the rise of korean cosmetics, this is one trend you’ll want to keep an eye on.
Let’s dive into why PDRN is quickly becoming a must-have ingredient in the modern skincare industry.

What is PDRN?
PDRN stands for polydeoxyribonucleotide. It’s a compound derived from fragments of salmon DNA — more specifically, it’s extracted from salmon testes and processed to be biocompatible with the human body. That means it’s purified and refined for safe use in skincare products and treatments. When you hear about PDRN, it’s natural to associate it with the image of a salmon!

Why is PDRN trending?
The reason why PDRN becomes trendy recently:
In Korea and across Asia
- there has been a growing desire for youthful-looking skin and inner radiance. Instead of opting for artificial or invasive treatments like fillers or surgical lifts, more people now prefer non-invasive anti-aging methods that focus on natural skin regeneration. This shift has made the Rejuran skin treatment, which contains PDRN, a popular choice in dermatology clinics.
Increasing Interest of at-home skincare
- On top of that, when the COVID-19 pandemic made it difficult to visit skin clinics, interest in at-home skincare skyrocketed. PDRN quickly gained attention for its marketing appeal as an ingredient that could “restore the skin without injections.” Riding the wave of credibility established by the Rejuran treatment, skincare brands began launching Rejuran ampoules and other home-care products, making PDRN more accessible to everyday consumers.
K-beauty spreading worldwide
- Over time, Rejuran evolved into a symbol of premium skin regeneration, firmly establishing PDRN as a core trend in Korean skincare. As the world became increasingly globalized and interest in K-beauty spread worldwide, Korea’s skincare trends began influencing global markets. This led to a surge in international curiosity about PDRN, its benefits, and how it relates to the Rejuran brand.
What is PDRN good for?
The pros of PDRN:
1. 🧬 Excellent Skin Regeneration Properties
Promotes the repair of damaged skin cells
Strengthens the skin barrier and improves elasticity
Helps reduce fine lines and rough texture
2. 💧 Hydration and Soothing Effects
Aids in maintaining moisture in the skin
Quickly calms irritated or reddened skin
3. 💉 Clinically Backed Ingredient
Originally used for burn wounds and post-surgical recovery
Its medical origins support its powerful regenerative effects
Strong enough to be injected in professional dermatology treatments
4. 👶 Suitable for Sensitive Skin
Minimal irritation and low risk of side effects
Generally safe even for sensitive or reactive skin types
What are the side effects or disadvantages of PDRN?
The cons of PDRN:
1. 💸 High Cost
The raw ingredient is expensive due to its complex extraction process from salmon DNA
Products containing PDRN are typically priced much higher than standard skincare
2. ⏳ Slow Results
Skin regeneration is a gradual process
Better suited for long-term maintenance rather than immediate results
3.🔍 Verifying Authenticity
Some products only claim to contain salmon DNA without meaningful concentrations
It's important to check the concentration, source, and purification method of the PDRN used
4. 🐟 Animal-Origin Concerns
Because it's extracted from salmon testes, it may not be ideal for consumers seeking vegan formulations

Examples of Products Containing PDRN
PDRN-based treatments
- Most commonly used in dermatology injections, such as Rejuran or other PDRN-based treatments
Skincare products with PDRN
- Also found in skincare products like ampoules, creams, and sheet masks
- Frequently included in high-end skincare lines
PDRN for sensitive skin
- Often recommended for sensitive skin or for those concerned about aging signs
Conclusion of what is PDRN with korean cosmetics
If you have sensitive skin or are looking to maintain a youthful appearance, it might be worth exploring skincare products that include PDRN. As you’ve learned in this guide, PDRN offers a unique blend of clinical credibility and real-world effectiveness.
If this content has sparked your interest in PDRN, why not consider creating your own personalized skincare product with Nextpangaea? And if you have any questions, feel free to reach out to us through our contact page — we’re always happy to help you build your dream formula.
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